Detection of OXA-1 β-Lactamase Gene of Klebsiella pneumoniae from Blood Stream Infections (BSI) by Conventional PCR and In-Silico Analysis to Understand the Mechanism of OXA Mediated Resistance

Klebsiella pneumoniae strains producing extended-spectrum β-lactamases (ESBL) exhibit resistance to antibiotic classes. The production of ESBLs (TEM-1, TEM-2, SHV-1, OXA-1) results in resistance to ampicillin, ticarcillin, piperacillin and cephalosporins. High levels of β-lactamases leads to develop...

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Bibliographic Details
Main Authors: Sugumar, Madhan, Kumar, K. M., Manoharan, Anand, Anbarasu, Anand, Ramaiah, Sudha
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960141/
https://ncbi.nlm.nih.gov/pubmed/24647004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091800
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