Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

The study of genetic influences on drug response and efficacy (‘pharmacogenetics’) has existed for over 50 years. Yet, we still lack a complete picture of how genetic variation, both common and rare, affects each individual's responses to medications. Exome sequencing is a promising alternative...

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Main Authors: Gordon, Adam S., Tabor, Holly K., Johnson, Andrew D., Snively, Beverly M., Assimes, Themistocles L., Auer, Paul L., Ioannidis, John P.A., Peters, Ulrike, Robinson, Jennifer G., Sucheston, Lara E., Wang, Danxin, Sotoodehnia, Nona, Rotter, Jerome I., Psaty, Bruce M., Jackson, Rebecca D., Herrington, David M., O'Donnell, Christopher J., Reiner, Alexander P., Rich, Stephen S., Rieder, Mark J., Bamshad, Michael J., Nickerson, Deborah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959810/
https://ncbi.nlm.nih.gov/pubmed/24282029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt588
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