Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats

BACKGROUND: We tested the hypothesis that direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), and examined the mechanism by which this occurs. METHODS AND RESULTS: Male SHR were treated (orally, 4 weeks) with...

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Detalhes bibliográficos
Main Authors: Zhang, Wen, Han, Yi, Meng, Guoliang, Bai, Wenli, Xie, Liping, Lu, Hui, Shao, Yongfeng, Wei, Lei, Pan, Shiyang, Zhou, Suming, Chen, Qi, Ferro, Albert, Ji, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959716/
https://ncbi.nlm.nih.gov/pubmed/24473199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000606
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