Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.

In addition to the five 70-kDa heat shock proteins (HSP70) common to germ cells and somatic tissues of mammals, spermatogenic cells synthesize HSP70-2 during meiosis. To determine if this unique stress protein has a critical role in meiosis, we used gene-targeting techniques to disrupt Hsp70-2 in mi...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Dix, D J, Allen, J W, Collins, B W, Mori, C, Nakamura, N, Poorman-Allen, P, Goulding, E H, Eddy, E M
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39594/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8622925/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.8.3264
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