Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin

Background: One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor). Methods: Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at...

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Hauptverfasser: Kolovou, Genovefa, Ragia, Georgia, Kolovou, Vana, Mihas, Constantinos, Katsiki, Niki, Vasiliadis, Ioannis, Mavrogeni, Sophie, Vartela, Vassiliki, Tavridou, Anna, Manolopoulos, Vangelis G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Bentham Open 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959175/
https://ncbi.nlm.nih.gov/pubmed/24653785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874192401408010012
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