Early MEK1/2 Inhibition after Global Cerebral Ischemia in Rats Reduces Brain Damage and Improves Outcome by Preventing Delayed Vasoconstrictor Receptor Upregulation

BACKGROUND: Global cerebral ischemia following cardiac arrest is associated with increased cerebral vasoconstriction and decreased cerebral blood flow, contributing to delayed neuronal cell death and neurological detriments in affected patients. We hypothesize that upregulation of contractile ET(B)...

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Detaylı Bibliyografya
Asıl Yazarlar: Johansson, Sara Ellinor, Larsen, Stine Schmidt, Povlsen, Gro Klitgaard, Edvinsson, Lars
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958517/
https://ncbi.nlm.nih.gov/pubmed/24642693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092417
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