VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain- and loss-of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor-B (VEGF-B) in the heart. A cardiomyocyte-specific VEGF-B transgene induced an expan...

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Bibliografiske detaljer
Main Authors: Kivelä, Riikka, Bry, Maija, Robciuc, Marius R, Räsänen, Markus, Taavitsainen, Miia, Silvola, Johanna MU, Saraste, Antti, Hulmi, Juha J, Anisimov, Andrey, Mäyränpää, Mikko I, Lindeman, Jan H, Eklund, Lauri, Hellberg, Sanna, Hlushchuk, Ruslan, Zhuang, Zhen W, Simons, Michael, Djonov, Valentin, Knuuti, Juhani, Mervaala, Eero, Alitalo, Kari
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958306/
https://ncbi.nlm.nih.gov/pubmed/24448490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303147
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