VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain- and loss-of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor-B (VEGF-B) in the heart. A cardiomyocyte-specific VEGF-B transgene induced an expan...

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Detalhes bibliográficos
Main Authors: Kivelä, Riikka, Bry, Maija, Robciuc, Marius R, Räsänen, Markus, Taavitsainen, Miia, Silvola, Johanna MU, Saraste, Antti, Hulmi, Juha J, Anisimov, Andrey, Mäyränpää, Mikko I, Lindeman, Jan H, Eklund, Lauri, Hellberg, Sanna, Hlushchuk, Ruslan, Zhuang, Zhen W, Simons, Michael, Djonov, Valentin, Knuuti, Juhani, Mervaala, Eero, Alitalo, Kari
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958306/
https://ncbi.nlm.nih.gov/pubmed/24448490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303147
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