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Development of a Luminex-Based Multiplex Assay for Detection of Mutations Conferring Resistance to Echinocandins in Candida glabrata

Echinocandins are the recommended treatment for invasive candidiasis due to Candida glabrata. Resistance to echinocandins is known to be caused by nonsynonymous mutations in the hot spot-1 (HS1) regions of the FKS1 and FKS2 genes, which encode a subunit of the β-1,3-glucan synthase, the target of ec...

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Библиографические подробности
Главные авторы: Pham, Cau D., Bolden, Carol B., Kuykendall, Randall J., Lockhart, Shawn R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957770/
https://ncbi.nlm.nih.gov/pubmed/24353003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.03378-13
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