Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis

Here we show that dynamin 2 (Dnm2) is essential for angiogenesis in vitro and in vivo. In cultured endothelial cells lacking Dnm2, vascular endothelial growth factor (VEGF) signaling and receptor levels are augmented whereas cell migration and morphogenesis are impaired. Mechanistically, the loss of...

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Detalhes bibliográficos
Main Authors: Lee, Monica Y., Skoura, Athanasia, Park, Eon Joo, Landskroner-Eiger, Shira, Jozsef, Levente, Luciano, Amelia K., Murata, Takahisa, Pasula, Satish, Dong, Yunzhou, Bouaouina, Mohamed, Calderwood, David A., Ferguson, Shawn M., De Camilli, Pietro, Sessa, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2014
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957370/
https://ncbi.nlm.nih.gov/pubmed/24598168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.104539
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