Targeting effector memory T cells with alefacept in new onset type 1 diabetes: 12 month results from the T1DAL study

BACKGROUND: Type 1 diabetes (T1D) results from autoimmune targeting of the pancreatic beta cells, likely mediated by effector memory T cells (Tems). CD2, a T cell surface protein highly expressed on Tems, is targeted by the fusion protein alefacept, depleting Tems and central memory T cells (Tcms)....

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Main Authors: Rigby, Mark R, DiMeglio, Linda A, Rendell, Marc S, Felner, Eric I, Dostou, Jean M, Gitelman, Stephen E, Patel, Chetanbabu M, Griffin, Kurt J, Tsalikian, Eva, Gottlieb, Peter A, Greenbaum, Carla J, Sherry, Nicole A, Moore, Wayne V, Monzavi, Roshanak, Willi, Steven M, Raskin, Philip, Moran, Antoinette, Russell, William E, Pinckney, Ashley, Keyes-Elstein, Lynette, Howell, Michael, Aggarwal, Sudeepta, Lim, Noha, Phippard, Deborah, Nepom, Gerald T, McNamara, James, Ehlers, Mario R
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957186/
https://ncbi.nlm.nih.gov/pubmed/24622414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-8587(13)70111-6
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