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Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?

Over recent decades, encouraging preclinical evidence using rodent models pointed to innovative pharmacological targets to treat major depressive disorder. However, subsequent clinical trials have failed to show convincing results. Two explanations for these rather disappointing results can be put f...

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Autor principal: Belzung, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957126/
https://ncbi.nlm.nih.gov/pubmed/24345817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.342
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