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Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
Sclerostin is a small protein expressed by the SOST gene in osteocytes, bone cells that respond to mechanical stress applied to the skeleton and appear to play an important role in the regulation of bone remodeling. When sclerostin binds to its receptors on the cell surface of osteoblasts, a downstr...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
SAGE Publications
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3956136/ https://ncbi.nlm.nih.gov/pubmed/24688605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1759720X13510479 |
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