A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

PURPOSE: Angiogenesis inhibition has emerged as a potentially promising treatment strategy for neuroendocrine tumors. 2-Methoxyestradiol (2ME2; Panzem®) is a natural derivative of estradiol with demonstrated anti-angiogenic activity in animal models. We performed a prospective, phase II study of 2ME...

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Huvudupphovsmän: Kulke, Matthew H., Chan, Jennifer A., Meyerhardt, Jeffrey A., Zhu, Andrew X., Abrams, Thomas A., Blaszkowsky, Lawrence S., Regan, Eileen, Sidor, Carolyn, Fuchs, Charles S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955980/
https://ncbi.nlm.nih.gov/pubmed/20960192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1478-7
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