Aberrant Activation, Nuclear Localization, and Phosphorylation of Yes-Associated Protein-1 in the Embryonic Kidney and Wilms Tumor

BACKGROUND: The Yes-associated-protein-1 (YAP1) is a novel, direct regulator of stem cell genes both in development and cancer. FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation. We hypot...

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Main Authors: Murphy, Andrew J., Pierce, Janene, de Caestecker, Christian, Libes, Jaime, Neblett, David, de Caestecker, Mark, Perantoni, Alan O., Tanigawa, Shunsuke, Anderson, James R., Dome, Jeffrey S., Das, Amrita, Carroll, Thomas J., Lovvorn, Harold N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955491/
https://ncbi.nlm.nih.gov/pubmed/24115727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24788
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