Aggressive dereplication using UHPLC–DAD–QTOF: screening extracts for up to 3000 fungal secondary metabolites

In natural-product drug discovery, finding new compounds is the main task, and thus fast dereplication of known compounds is essential. This is usually performed by manual liquid chromatography-ultraviolet (LC-UV) or visible light-mass spectroscopy (Vis-MS) interpretation of detected peaks, often as...

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Bibliographic Details
Main Authors: Klitgaard, Andreas, Iversen, Anita, Andersen, Mikael R., Larsen, Thomas O., Frisvad, Jens Christian, Nielsen, Kristian Fog
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955480/
https://ncbi.nlm.nih.gov/pubmed/24442010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-013-7582-x
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