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Hemoglobin as a Nitrite Anhydrase: Modeling Methemoglobin-Mediated N(2)O(3) Formation

Nitrite has recently been recognized as a storage form of NO in blood and as playing a key role in hypoxic vasodilation. The ion is readily reduced to NO by hemoglobin in red blood cells, which, however, also presents a conundrum. Given NO’s enormous affinity of ferrous heme, a key question concerns...

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Bibliographic Details
Main Authors: Hopmann, Kathrin H., Cardey, Bruno, Gladwin, Mark T., Kim-Shapiro, Daniel B., Ghosh, Abhik
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954847/
https://ncbi.nlm.nih.gov/pubmed/21590821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201003578
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