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Hemoglobin as a Nitrite Anhydrase: Modeling Methemoglobin-Mediated N(2)O(3) Formation
Nitrite has recently been recognized as a storage form of NO in blood and as playing a key role in hypoxic vasodilation. The ion is readily reduced to NO by hemoglobin in red blood cells, which, however, also presents a conundrum. Given NO’s enormous affinity of ferrous heme, a key question concerns...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954847/ https://ncbi.nlm.nih.gov/pubmed/21590821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201003578 |
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