Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

We have previously reported down-regulation of mRNA expression of some of the kappa light chain transgenes in a hybridoma derived from a secondary immune response. Of the five heavily mutated transgene copies present in that hybridoma, three included premature stop codons and were poorly represented...

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Pubblicato in:	EMBO J
Autori principali:	Lozano, F, Maertzdorf, B, Pannell, R, Milstein, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395394/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7925302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06783.x
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