An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.

The amiloride-sensitive Na+ channel constitutes the rate-limiting step for Na+ transport in epithelia. Immunolocalization and electrophysiological studies have demonstrated that this channel is localized at the apical membrane of polarized epithelial cells. This localization is essential for proper...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Rotin, D, Bar-Sagi, D, O'Brodovich, H, Merilainen, J, Lehto, V P, Canessa, C M, Rossier, B C, Downey, G P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395375/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7925286/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06766.x
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