Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.

Hereditary hyperekplexia is a dominant neurological disorder associated with point mutations at the channel-forming segment M2 of the glycine receptor alpha 1 subunit. Voltage-clamp recordings from the heterologously expressed mutants (alpha 1R271L or alpha 1R271Q) revealed 146- to 183-fold decrease...

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	EMBO J
Prif Awduron:	Langosch, D, Laube, B, Rundström, N, Schmieden, V, Bormann, J, Betz, H
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Publishing Group 1994
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395349/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7925268/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06742.x
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!