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Unbiased, scalable sampling of protein loop conformations from probabilistic priors

BACKGROUND: Protein loops are flexible structures that are intimately tied to function, but understanding loop motion and generating loop conformation ensembles remain significant computational challenges. Discrete search techniques scale poorly to large loops, optimization and molecular dynamics te...

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Detalhes bibliográficos
Main Authors: Zhang, Yajia, Hauser, Kris
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953323/
https://ncbi.nlm.nih.gov/pubmed/24565175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-13-S1-S9
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