Nitration of Tyrosine 247 Inhibits Protein Kinase G-1α Activity by Attenuating Cyclic Guanosine Monophosphate Binding

The cGMP-dependent protein kinase G-1α (PKG-1α) is a downstream mediator of nitric oxide and natriuretic peptide signaling. Alterations in this pathway play a key role in the pathogenesis and progression of vascular diseases associated with increased vascular tone and thickness, such as pulmonary hy...

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Detalhes bibliográficos
Main Authors: Aggarwal, Saurabh, Gross, Christine M., Rafikov, Ruslan, Kumar, Sanjiv, Fineman, Jeffrey R., Ludewig, Britta, Jonigk, Danny, Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953305/
https://ncbi.nlm.nih.gov/pubmed/24469460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534313
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