Novel Regulation of CD80/CD86-induced Phosphatidylinositol 3-Kinase Signaling by NOTCH1 Protein in Interleukin-6 and Indoleamine 2,3-Dioxygenase Production by Dendritic Cells

Dendritic cells (DC) play a critical role in modulating antigen-specific immune responses elicited by T cells via engagement of the prototypic T cell costimulatory receptor CD28 by the cognate ligands CD80/CD86, expressed on DC. Although CD28 signaling in T cell activation has been well characterize...

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Autors principals: Koorella, Chandana, Nair, Jayakumar R., Murray, Megan E., Carlson, Louise M., Watkins, Stephanie K., Lee, Kelvin P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953285/
https://ncbi.nlm.nih.gov/pubmed/24415757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519686
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