Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

Translation of ferritin and erythroid 5-aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA-protein interactions between iron-responsive elements (IREs) and iron regulatory protein (IRP). In iron-depleted cells, IRP binds to single IREs located in the 5' untranslated regions of ferr...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Gray, N K, Hentze, M W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395301/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8070415/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06699.x
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