Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum.

The alpha beta T-cell antigen receptor (TCR) is a multisubunit transmembrane complex composed of at least six different proteins (alpha, beta, gamma, delta, epsilon and zeta) that are assembled in the endoplasmic reticulum (ER). In this report we have examined the role of oligosaccharide processing...

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Vydáno v:	EMBO J
Hlavní autoři:	Kearse, K P, Williams, D B, Singer, A
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7915231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06677.x
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