Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.

p185erbB-2 and p180erbB-4 are epidermal growth factor (EGF) receptor-like tyrosine kinases, whose co-expression is observed in many breast carcinomas. Heregulins (HRGs), which contain an immunoglobulin unit and an EGF-like domain, bind to p180erbB-4 and activate p180erbB-4 and p185erbB-2 through tra...

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Autors principals: Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Matsuda, S, Yamamoto, T, Suzuki, A, Inagaki, F
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC395255/
https://ncbi.nlm.nih.gov/pubmed/8062828
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