Characterization of dynamics in complex lyophilized formulations: II. Analysis of density variations in terms of glass dynamics and comparisons with global mobility, fast dynamics, and Positron Annihilation Lifetime Spectroscopy (PALS)

Amorphous HES/disaccharide (trehalose or sucrose) formulations, with and without added polyols (glycerol and sorbitol) and disaccharide formulations of human growth hormone (hGH), were prepared by freeze drying and characterized with particular interest in methodology for using high precision densit...

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Bibliografiske detaljer
Main Authors: Chieng, Norman, Cicerone, Marcus T., Zhong, Qin, Liu, Ming, Pikal, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952238/
https://ncbi.nlm.nih.gov/pubmed/23623797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2013.03.036
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