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Transient activation of Hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation

PURPOSE: To examine effects and mechanisms of transient activation of Hedgehog pathway on rescuing radiotherapy-induced hyposalivation in head and neck cancer survivors. EXPERIMENTAL DESIGN: Mouse salivary glands and cultured human salivary epithelial cells were irradiated by single 15Gy dose. Hedge...

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Библиографические подробности
Главные авторы: Hai, Bo, Qin, Lizheng, Yang, Zhenhua, Zhao, Qingguo, Shangguan, Lei, Ti, Xinyu, Zhao, Yanqiu, Kim, Sangroh, Rangaraj, Dharanipathy, Liu, Fei
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951215/
https://ncbi.nlm.nih.gov/pubmed/24150232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1434
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