Novel Point Mutations and A8027G Polymorphism in Mitochondrial-DNA-Encoded Cytochrome c Oxidase II Gene in Mexican Patients with Probable Alzheimer Disease

Mitochondrial dysfunction has been thought to contribute to Alzheimer disease (AD) pathogenesis through the accumulation of mitochondrial DNA mutations and net production of reactive oxygen species (ROS). Mitochondrial cytochrome c-oxidase plays a key role in the regulation of aerobic production of...

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Autors principals: Loera-Castañeda, Verónica, Sandoval-Ramírez, Lucila, Pacheco Moisés, Fermín Paul, Macías-Islas, Miguel Ángel, Alatorre Jiménez, Moisés Alejandro, González-Renovato, Erika Daniela, Cortés-Enríquez, Fernando, Célis de la Rosa, Alfredo, Velázquez-Brizuela, Irma E., Ortiz, Genaro Gabriel
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950951/
https://ncbi.nlm.nih.gov/pubmed/24701363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/794530
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