Ligand Binding Promotes CDK-Dependent Phosphorylation of ER-Alpha on Hinge Serine 294 but Inhibits Ligand-Independent Phosphorylation of Serine 305

Phosphorylation of estrogen receptor-α (ERα) is critical for its transcription factor activity and may determine its predictive and therapeutic value as a biomarker for ERα-positive breast cancers. Recent attention has turned to the poorly understood ERα hinge domain, as phosphorylation at serine 30...

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Bibliographic Details
Main Authors: Held, Jason M., Britton, David J., Scott, Gary K., Lee, Elbert L., Schilling, Birgit, Baldwin, Michael A., Gibson, Bradford W., Benz, Christopher C.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950940/
https://ncbi.nlm.nih.gov/pubmed/22669764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0099
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