Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells

Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to improve the survival rate of patients with advanced HER2-positive breast cancers. However, the off-target activity of lapatinib in inducing EGFR expression without tyrosine kinase activity was demonstrated to render HER2-negati...

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Detalhes bibliográficos
Main Authors: Tu, Chih-Yen, Chen, Chia-Hung, Hsia, Te-Chun, Hsu, Min-Hsiang, Wei, Ya-Ling, Yu, Meng-Chieh, Chen, Wen-Shu, Hsu, Ke-Wei, Yeh, Ming-Hsin, Liu, Liang-Chih, Chen, Yun-Ju, Huang, Wei-Chien
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950925/
https://ncbi.nlm.nih.gov/pubmed/24707474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/168949
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