Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

BACKGROUND: In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed. METHOD...

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Main Authors: Walters, M J, Ebsworth, K, Berahovich, R D, Penfold, M E T, Liu, S-C, Al Omran, R, Kioi, M, Chernikova, S B, Tseng, D, Mulkearns-Hubert, E E, Sinyuk, M, Ransohoff, R M, Lathia, J D, Karamchandani, J, Kohrt, H E K, Zhang, P, Powers, J P, Jaen, J C, Schall, T J, Merchant, M, Recht, L, Brown, J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950859/
https://ncbi.nlm.nih.gov/pubmed/24423923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.830
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