Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase

All positive-stranded RNA viruses with genomes >∼7 kb encode helicases, which generally are poorly characterized. The core of the nidovirus superfamily 1 helicase (HEL1) is associated with a unique N-terminal zinc-binding domain (ZBD) that was previously implicated in helicase regulation, genome...

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Hlavní autoři: Deng, Zengqin, Lehmann, Kathleen C., Li, Xiaorong, Feng, Chong, Wang, Guoqiang, Zhang, Qi, Qi, Xiaoxuan, Yu, Lin, Zhang, Xingliang, Feng, Wenhai, Wu, Wei, Gong, Peng, Tao, Ye, Posthuma, Clara C., Snijder, Eric J., Gorbalenya, Alexander E., Chen, Zhongzhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950703/
https://ncbi.nlm.nih.gov/pubmed/24369429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1310
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