Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) deposition, which activates microglia, induces neuroinflammation and drives neurodegeneration. Recent evidence indicates that soluble pre-fibrillar Aβ species, rather than insoluble fibrils, are the most toxic forms of Aβ...

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Detalhes bibliográficos
Main Authors: Joshi, P, Turola, E, Ruiz, A, Bergami, A, Libera, D D, Benussi, L, Giussani, P, Magnani, G, Comi, G, Legname, G, Ghidoni, R, Furlan, R, Matteoli, M, Verderio, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950321/
https://ncbi.nlm.nih.gov/pubmed/24336048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.180
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