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High Iodine Blocks a Notch/miR-19 Loop Activated by the BRAF(V600E) Oncoprotein and Restores the Response to TGFβ in Thyroid Follicular Cells
Background: Excess iodine inhibits thyroid follicular cell proliferation associated with TGFβ pathway activation, although thyroid cancers are frequently refractory to TGFβ signaling. The TGFβ pathway is predicted to be regulated by miR-17-92 cluster microRNAs. MicroRNAs are small noncoding RNAs tha...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Mary Ann Liebert, Inc.
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949441/ https://ncbi.nlm.nih.gov/pubmed/23998804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2013.0398 |
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