Direct Detection of a Sulfonate Ester Genotoxic Impurity by Atmospheric-Pressure Thermal Desorption–Extractive Electrospray–Mass Spectrometry

[Image: see text] A direct, ambient ionization method has been developed using atmospheric pressure thermal desorption–extractive electrospray–mass spectrometry (AP/TD-EESI-MS) for the detection of the genotoxic impurity (GTI) methyl p-toluenesulfonate (MTS) in a surrogate pharmaceutical matrix. A c...

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Auteurs principaux: Devenport, Neil A., Sealey, Laura C., Alruways, Faisal H., Weston, Daniel J., Reynolds, James C., Creaser, Colin S.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2013
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949410/
https://ncbi.nlm.nih.gov/pubmed/23750985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac401054n
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