Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin-deficient mice

Adiponectin is an adipose-derived hormone with anti-inflammatory activity. Following subacute ozone exposure (0.3 ppm for 24–72 h), neutrophilic inflammation and IL-6 are augmented in adiponectin-deficient (Adipo(−/−)) mice. The IL-17/granulocyte colony-stimulating factor (G-CSF) axis is required fo...

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Main Authors: Kasahara, David I., Kim, Hye Y., Mathews, Joel A., Verbout, Norah G., Williams, Alison S., Wurmbrand, Allison P., Ninin, Fernanda M. C., Neto, Felippe L., Benedito, Leandro A. P., Hug, Christopher, Umetsu, Dale T., Shore, Stephanie A.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949085/
https://ncbi.nlm.nih.gov/pubmed/24381131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00235.2013
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