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4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
It has previously been argued that the repressor of protein synthesis initiation factor 4E, 4E-BP1, is a direct in vivo target of p42mapk. However, the immunosuppressant rapamycin blocks serum-induced 4E-BP1 phosphorylation and, in parallel, p70s6k activation, with no apparent effect on p42mapk acti...
में बचाया:
मुख्य लेखकों: | , , , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
1996
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC39489/ https://ncbi.nlm.nih.gov/pubmed/8633019 |
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