β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice

Lipotoxic cardiomyopathy is caused by myocardial lipid accumulation and often occurs in patients with diabetes and obesity. This study investigated the effects of β-lapachone (β-lap), a natural compound that activates Sirt1 through elevation of the intracellular NAD(+) level, on acyl CoA synthase (A...

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Autori principali: Jeong, Moon Hee, Tran, Nguyen Khoi Song, Kwak, Tae Hwan, Park, Byung Keon, Lee, Chul Soon, Park, Tae-Sik, Lee, Young-Hoon, Park, Woo Jin, Yang, Dong Kwon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948739/
https://ncbi.nlm.nih.gov/pubmed/24614171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091039
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