β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice

Lipotoxic cardiomyopathy is caused by myocardial lipid accumulation and often occurs in patients with diabetes and obesity. This study investigated the effects of β-lapachone (β-lap), a natural compound that activates Sirt1 through elevation of the intracellular NAD(+) level, on acyl CoA synthase (A...

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Main Authors: Jeong, Moon Hee, Tran, Nguyen Khoi Song, Kwak, Tae Hwan, Park, Byung Keon, Lee, Chul Soon, Park, Tae-Sik, Lee, Young-Hoon, Park, Woo Jin, Yang, Dong Kwon
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948739/
https://ncbi.nlm.nih.gov/pubmed/24614171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091039
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