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Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas

Pancreatic cancer is one of the deadliest human malignancies. A striking feature of pancreatic cancer is that activating Kras mutations are found in ∼90% of cases. However, apart from a restricted population of cells expressing pancreatic and duodenal homeobox 1 (PDX1), most pancreatic cells are ref...

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Hlavní autoři: Ischenko, Irene, Petrenko, Oleksi, Hayman, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948305/
https://ncbi.nlm.nih.gov/pubmed/24550494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319911111
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