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Functional differences between the two splice variants of the nucleolar transcription factor UBF: the second HMG box determines specificity of DNA binding and transcriptional activity.

The nucleolar transcription factor UBF consists of two proteins, UBF1 and UBF2, which originate by alternative splicing. Here we show that deletion of 37 amino acids within the second of five HMG box motifs in UBF2 is important for the dual role of UBF as transcriptional activator and antirepressor....

Celý popis

Uloženo v:
Vydáno v:EMBO J
Hlavní autoři: Kuhn, A, Voit, R, Stefanovsky, V, Evers, R, Bianchi, M, Grummt, I
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394823/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8313887/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06276.x
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