NFIL3 deficient mice develop microbiota dependent, IL-12/23 driven spontaneous colitis

NFIL3 (nuclear factor, IL-3 regulated) is a transcription factor that regulates multiple immunologic functions. In myeloid cells, NFIL3 is IL-10 inducible, and has a key role as a repressor of IL-12p40 transcription. NFIL3 is a susceptibility gene for the human inflammatory bowel diseases. Here we d...

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Hauptverfasser: Kobayashi, Taku, Steinbach, Erin C., Russo, Steven M., Matsuoka, Katsuyoshi, Nochi, Tomonori, Maharshak, Nitsan, Borst, Luke B., Hostager, Bruce, Garcia-Martinez, J. Victor, Rothman, Paul B., Kashiwada, Masaki, Sheikh, Shehzad Z., Murray, Peter J., Plevy, Scott E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948213/
https://ncbi.nlm.nih.gov/pubmed/24442434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301819
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