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Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t (1/2)) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd) is 1.1 L/kg both in neonates and adults. M...
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| 格式: | Artigo |
| 語言: | Inglês |
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Hindawi Publishing Corporation
2014
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948203/ https://ncbi.nlm.nih.gov/pubmed/24696691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/309342 |
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