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Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review

Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t (1/2)) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd) is 1.1 L/kg both in neonates and adults. M...

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Detalhes bibliográficos
Autor principal: Pacifici, Gian Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948203/
https://ncbi.nlm.nih.gov/pubmed/24696691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/309342
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