Chaperonin-facilitated protein folding: optimization of rate and yield by an iterative annealing mechanism.
We develop a heuristic model for chaperonin-facilitated protein folding, the iterative annealing mechanism, based on theoretical descriptions of "rugged" conformational free energy landscapes for protein folding, and on experimental evidence that (i) folding proceeds by a nucleation mechanism whereb...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4030 |
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