Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia

PURPOSE: Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on sa...

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Detaylı Bibliyografya
Asıl Yazarlar: Bhojwani, Deepa, Sabin, Noah D., Pei, Deqing, Yang, Jun J., Khan, Raja B., Panetta, John C., Krull, Kevin R., Inaba, Hiroto, Rubnitz, Jeffrey E., Metzger, Monika L., Howard, Scott C., Ribeiro, Raul C., Cheng, Cheng, Reddick, Wilburn E., Jeha, Sima, Sandlund, John T., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Clinical Oncology 2014
Konular:
ORIGINAL REPORTS
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948096/
https://ncbi.nlm.nih.gov/pubmed/24550419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.53.0808
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