Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia

PURPOSE: Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on sa...

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Main Authors: Bhojwani, Deepa, Sabin, Noah D., Pei, Deqing, Yang, Jun J., Khan, Raja B., Panetta, John C., Krull, Kevin R., Inaba, Hiroto, Rubnitz, Jeffrey E., Metzger, Monika L., Howard, Scott C., Ribeiro, Raul C., Cheng, Cheng, Reddick, Wilburn E., Jeha, Sima, Sandlund, John T., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2014
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ORIGINAL REPORTS
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948096/
https://ncbi.nlm.nih.gov/pubmed/24550419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.53.0808
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