Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia

PURPOSE: Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on sa...

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Bibliografski detalji
Glavni autori: Bhojwani, Deepa, Sabin, Noah D., Pei, Deqing, Yang, Jun J., Khan, Raja B., Panetta, John C., Krull, Kevin R., Inaba, Hiroto, Rubnitz, Jeffrey E., Metzger, Monika L., Howard, Scott C., Ribeiro, Raul C., Cheng, Cheng, Reddick, Wilburn E., Jeha, Sima, Sandlund, John T., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2014
Teme:
ORIGINAL REPORTS
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948096/
https://ncbi.nlm.nih.gov/pubmed/24550419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.53.0808
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