Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium

Women exposed to diethylstilbestrol (DES) in utero frequently develop vaginal adenosis, from which clear cell adenocarcinoma can arise. Despite decades of extensive investigation, the molecular pathogenesis of DES-associated vaginal adenosis remains elusive. Here we report that DES induces vaginal a...

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Detalhes bibliográficos
Main Authors: Laronda, Monica M., Unno, Kenji, Ishi, Kazutomo, Serna, Vanida A., Butler, Lindsey M., Mills, Alea A., Orvis, Grant D., Behringer, Richard R., Deng, Chuxia, Sinha, Satrajit, Kurita, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947918/
https://ncbi.nlm.nih.gov/pubmed/23830984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2013.06.024
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