Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

ISGF2 was initially identified, purified and cloned as an interferon-alpha (IFN alpha) induced transcription factor that binds to the IFN-stimulated response element (ISRE) of IFN alpha/beta-stimulated genes (ISGs). It was reported to be transcriptionally regulated by several cytokines including IFN...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Pine, R, Canova, A, Schindler, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8306959/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06245.x
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