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Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain.

Upon insertion of a signal-anchor protein into the endoplasmic reticulum membrane, either the C-terminal or the N-terminal domain is translocated across the membrane. Charged residues flanking the transmembrane domain are important determinants for this decision, but are not necessarily sufficient t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Denzer, A J, Nabholz, C E, Spiess, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC394755/
https://ncbi.nlm.nih.gov/pubmed/8557050
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